Pancreas Transplantation

• Pancreas transplantation E-Book
• Who Should Be Considered for Islet Transplantation Alone?
  
• Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia
• Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention.
• Islet cell transplants for Type 1 diabetes
• Collaborative Islet Transplant Registery
• Odorico JS, Sollinger HW. Technical and immunological advances in transplantation for insulin dependant diabetes mellitus.
• Baranski AG, Lam HD, Braat AE , Schaapherder AF. The dorsal pancreatic artery in pancreas procurement and transplantation: anatomical considerations and potential implications.
• Berney T, Badet L. Pancreas transplantation In Transplantation Surgery ed.
• S.A. White, J.A. Shaw, D.E. Sutherland. Pancreas transplantation
• D.E. Sutherland, R.W. Gruessner, D.L. Dunn, et al. Lessons learned from more than 1,000 pancreas transplants at a single institution.
• J.R. Dillman, K.M. Elsayes, R.O. Bude, et al. Imaging of pancreas transplants: postoperative findings with clinical correlation.
• F.Q. Vandermeer, M.A. Manning, A.A. Frazier, et al. Imaging of whole-organ pancreas transplants.
• Adam D. Barlow, Kourosh Saeb-Parsy, Christopher J. E. Watson. An analysis of the survival outcomes of simultaneous pancreas and kidney transplantation compared to live donor kidney transplantation in patients with type 1 diabetes
• Computational flow cytometry
• Closed-loop for type 1 diabetes / an introduction and appraisal for the generalist
• A Review of Safety and Design Requirements of the Artificial Pancreas
• Future of Automated Insulin Delivery Systems
• Coming of age: the artificial pancreas for type 1 diabetes
• Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery
• MD-Logic Overnight Control for 6 Weeks of Home Use in Patients With Type 1 Diabetes: Randomized Crossover Trial
• Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes
• Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial
• Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes
• Glucagon in arti fi cial pancreas systems: Potential bene fi ts and safety pro fi le of future chronic use
• Home Use of an Artificial Beta Cell in Type 1 Diabetes
• Coming of age: the artificial pancreas for type 1 diabetes
• Outcomes after simultaneous pancreas and kidney transplantation an d the discriminative ability of the C-peptide measurement pretransplant among type 1 and type 2 diabetes mellitus.
• Glucose homeostasis after sim ultaneous pancreas and kidney transplantation: a comparison of subjects with C-peptide-positive non-type 1 diabetes mellitus and type 1 diabetes mellitus.
• Simultaneous pancreas-kidney transplants in type I and type II diabetic patients with end- stage renal disease: similar 10-year outcomes.
• Simultaneous pancreas kidney transplants in diabetic patients with end-stage renal disease: the 20-yr experience.
• Combined pancreas-kidney transpl antation for patients with end-stage nephropathy caused by type-2 diabetes mellitus.
• Successful long-term kidney-pancreas transplants in diabetic patients with high C-peptide levels.
• Long-term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
• Do pretransplant C-peptide levels influence outcomes in simultaneous kidney-pancreas transplantation?
• Pancreas transplantation in C-peptide positive pa tients: does "type" of diabetes really matter?
• Simultaneous Pancr eas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus?
• Outcomes of simultaneous pancreas-ki dney transplantation in type 2 diabetic recipients.
• Simultaneous pancreas kidney transplant versus other kidney transplant options in pa tients with type 2 diabetes.
• Type 2 diabetes: is pancreas transplantation an option?
• Type 2 diabetes: the best transplant option is still uncertain.
• Pancreas transplantation for type 2 diabetes mellitus.
• Is there a role for pancreas transplantation in type 2 diabetes mellitus?
• Pancreas transplantation in type II diabetes mellitus.
• Combined pancreas and kidney transplantation in a lean type 2 diabetic patient. Effects on insulin secretion and sensitivity.
• Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and ki dney transplantation?
• Successful simultaneous pancreas kidney transplantation in maturity-onset diabetes of the young type 5
• Maturity onset diabetes of the young: clinical characteristics and outcome after kidney and pancreas transplantation in MODY3 and RCAD patients: a single center experience.
• Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis.
• The accelerator hypothesis: weight gain as the missing l ink between Type I and Type II diabetes.
• The accelerator hypothesis: a review of the evidence for i nsulin resistance as the basis for type I as well as type II diabetes.

Why do we need beta cell replacement when there is insulin? (Lorenzo Piemonte)

• Understanding glucose levels in healthy subjects
• Efficacy of insulin treatment in Type 1 diabetes patients
• Advantages of beta cell replacement over insulin treatment

Reception Selection: Pancreas and Islet transplantation alone (Pratik Choudhary)

• Identifying patients with problematic hypoglycaemia
• What is the pathway for someone with problematic hypoglycemia?
• Indications for pancreas or islet transplantation

Recipient selection: pancreas transplantation or islet grafting in uremic patients? (Olivier Thaunat)

• Diabetes-induced vascualar complications: impact of uremia
• Beta cell replacement in uremic T1D patient
• Indications for islet grafting in uremic T1D patient

Recipient selection for pancreas or islet transplantation (Thierry Berney)

• Introduction
• Current status of pancreas vs islet transplantation
• Preferred indications
• Risk/benefit assessment: how are the goals achieved?
• Risk/benefit assessment: the risks
• Summary and decision algorithm

Pancreas transplantation for type 2 diabetes (Olivier Thaunat)

• Introduction
• What defines type 2 diabetes?
• In which type 2 diabetes?
• What is the activity?
• How do you select candidates?

Evolving approaches to organ allocation for whole pancreas versus islet transplantation (James Shaw)

• Factors to consider for a fair and effective organ allocation scheme
• Predictors of pancreas transplant outcome
• Predictors of islet transplant outcome
• Predictors of islet isolation and transplant outcome
• Evolution of pancreas and islet transplantation in the UK
• The UK allocation scheme: design and outcomes

Pancreas transplantation: the surgical procedure and its variation (Gabriel Oniscu)

• Indications for, and types of, pancreas transplantation
• Bench surgery preparation
• Most common implantation technique
• Technical variations

Technical complications of pancreas transplantation (Gabriel Oniscu)

• Introduction and overview
• Risk factors for technical complications
• Most common technical complications
• Other technical complications

Immunosuppressive regiments in pancreas and islet transplantation (Olivier Thaunat)

• Pathophysiology and treatment of pancreas Tx rejection
• Maintenance immunosuppression in pancreas transplantation
• Immunosuppression in islet grafting

Outcome measures of immunologic mechanisms (Paolo Monti)

• Immune monitoring of auto reactive T cell responses
• The CFSE dilution assay
• Staining with HLA-peptide multimers
• High dimensional flow cytometry
• Conclusions and next step

The incidence, diagnosis and management of pancreas rejection (biopsy) (Fabio Vistoli)

• Introduction
• Pancreas rejection incidence
• Pancreas rejection diagnosis
• Pancreas rejection management - biopsy indication
• Pancreas rejection management - biopsy procedure

Towards the artificial pancreas (Daniela Bruttomesso)

• Articial Pancreas: background and foundation
• Uni-hormonal artificial pancreas: clinical evidence
• The bi-hormonal articial pancreas
• Towards commercialisation
• User acceptance and possible improvements